Similar efficacy and safety of initial COBRA-light and COBRA therapy in rheumatoid arthritis: 4-year results from the COBRA-light trial
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چکیده
منابع مشابه
Cost-utility of COBRA-light versus COBRA therapy in patients with early rheumatoid arthritis: the COBRA-light trial
Objective To evaluate if COmbinatie therapie Bij Reumatoïde Artritis (COBRA)-light therapy is cost-effective in treating patients with early rheumatoid arthritis (RA) compared with COBRA therapy. Methods This economic evaluation was performed next to the open-label, randomised non-inferiority COBRA-light trial in 164 patients with early RA. Non-responders to COBRA or COBRA-light received etan...
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متن کاملDiscordant perspectives of rheumatologists and patients on COBRA combination therapy in rheumatoid arthritis.
OBJECTIVE The COBRA therapy (combination therapy in early rheumatoid arthritis) has proven to be an effective treatment for early RA, but is rarely prescribed. A survey showed reluctance of Dutch reumatologists to apply COBRA therapy in early RA. The present qualitative study was carried out to further explore the reservation of Dutch rheumatologists towards prescribing COBRA therapy and includ...
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i chlor. injected in the adjoining area of the bitten part. 1 a.m. Severe pain in the arm. Rubber cord and handkerchief removed. 1-30 a.m. Pulse 64. Resp. 24. Temp. 98. Calm and quiet. No sleep. Spt. ammon. arom. half drachm. 2 a.m. Pulse 64. Resp. 24. 2-30 a.m. Shivering. Hot coffee to drink. 3 a.m. Pulse 64. Resp. 24. Drowsy. 3-30 a.m. Vomited. Pulse 60. Resp. 26. Temp. 98. 3-45 a.m. Getting ...
متن کاملA non-inferiority trial of an attenuated combination strategy (‘COBRA-light’) compared to the original COBRA strategy: clinical results after 26 weeks
BACKGROUND Early, intensive treatment of rheumatoid arthritis (RA) with the combination of (initially high dose) prednisolone, methotrexate and sulfasalazine (COBRA therapy) considerably lowers disease activity and suppresses radiological progression, but is infrequently prescribed in daily practice. Attenuating the COBRA regimen might lessen concerns about side effects, but the efficacy of suc...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2017
ISSN: 1462-0324,1462-0332
DOI: 10.1093/rheumatology/kex223